Assuntos
Anticorpos Biespecíficos/uso terapêutico , Leucemia Aguda Bifenotípica/tratamento farmacológico , Neoplasia Residual/tratamento farmacológico , Leucemia-Linfoma Linfoblástico de Células Precursoras B/tratamento farmacológico , Idoso , Anticorpos Biespecíficos/administração & dosagem , Anticorpos Biespecíficos/farmacologia , Antígenos CD19/efeitos dos fármacos , Antígenos CD19/genética , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Terapia Combinada/métodos , Feminino , Transplante de Células-Tronco Hematopoéticas/métodos , Histona-Lisina N-Metiltransferase/efeitos dos fármacos , Histona-Lisina N-Metiltransferase/genética , Humanos , Lactente , Leucemia Aguda Bifenotípica/genética , Leucemia Aguda Bifenotípica/patologia , Masculino , Proteína de Leucina Linfoide-Mieloide/efeitos dos fármacos , Proteína de Leucina Linfoide-Mieloide/genética , Neoplasia Residual/genética , Neoplasia Residual/patologia , Leucemia-Linfoma Linfoblástico de Células Precursoras B/genética , Leucemia-Linfoma Linfoblástico de Células Precursoras B/patologia , Intervalo Livre de Progressão , Indução de Remissão , Resultado do TratamentoRESUMO
The recent developments and evidence for the effect of polyphenol components of berries on digestive enzymes has been reviewed. Certain plant polyphenols can inhibit starch digestive enzymes in the gastrointestinal tract and modulate blood glucose control in vivo. Certain berry polyphenol components can inhibit protease activities at levels which could affect protein digestion in the gastrointestinal tract. In addition, other polyphenol components show potential for the inhibition of gastrointestinal lipase activity, which is a proven therapeutic target for the control of obesity through reduced fat digestion. Taking into account the potential synergies for inhibition of starch and lipid digestion by the spectrum of polyphenol components present within berry species, the inhibition of digestive enzymes by dietary polyphenols may be another important mechanism for the health benefits attributed to a diet rich in fruit and vegetables.
